
Find hotels in Medical Center District, San Antonio
Check prices for these dates
Our top choices for Medical Center District hotels

1. Drury Plaza Hotel San Antonio Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
2. Hotel Valencia Riverwalk, Valencia Collection
Hotel Valencia Riverwalk, Valencia Collection
3. Riverwalk Plaza
Riverwalk Plaza
4. Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
5. Menger Hotel
Menger Hotel
6. The Westin San Antonio North
The Westin San Antonio North
7. Omni La Mansion del Rio
Omni La Mansion del Rio
8. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
9. Hotel Contessa
Hotel Contessa
10. Hyatt Regency San Antonio Riverwalk
Hyatt Regency San Antonio Riverwalk
11. La Cantera Resort & Spa, a Signia Hilton Resort
La Cantera Resort & Spa, a Signia Hilton Resort
12. Hyatt Regency Hill Country Resort and Villas
Hyatt Regency Hill Country Resort and Villas
13. Hotel 1914 - Historic Alamo Riverwalk, an Ascend Collection Hotel
Hotel 1914 - Historic Alamo Riverwalk, an Ascend Collection Hotel
14. San Antonio Marriott Northwest Medical Center
San Antonio Marriott Northwest Medical Center
15. Drury Inn & Suites San Antonio Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
16. La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
17. Crockett Hotel
Crockett Hotel
18. Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
19. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
20. La Quinta Inn & Suites by Wyndham San Antonio Downtown
La Quinta Inn & Suites by Wyndham San Antonio DowntownCompare popular hotels in Medical Center District
Property | Star rating | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() Drury Inn & Suites San Antonio Northwest Medical Center | 9.2 Wonderful 1,535 reviews | View | ||||||
![]() Fairfield Inn & Suites by Marriott San Antonio Medical Center | 9.0 Wonderful 1,116 reviews | View | ||||||
![]() Courtyard by Marriott Medical Center San Antonio | 8.8 Excellent 1,002 reviews | View | ||||||
![]() San Antonio Marriott Northwest Medical Center | 8.6 Excellent 1,200 reviews | View | ||||||
![]() La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW | 8.4 Very good 3,781 reviews | View |
Where to stay in Medical Center District

Downtown San Antonio
Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Uptown Central
While visiting Uptown Central, you might make a stop by sights like Marion Koogler McNay Art Museum and Alamo Quarry Market.

Far West Side
While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Northwest Side
While visiting Northwest Side, you might make a stop by sights like Huebner Oaks and Crystal Ice Palace.

Stone Oak
Travelers come to Stone Oak for its abundant dining options, and you can see top attractions like Shops at Hardy Oak and Alta Vista at Stone Oak while you're in town.
Top Medical Center District Hotel Reviews

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
Frequently asked questions
Explore a world of travel with Expedia
- Arsenal Hotels
- Near East Side Hotels
- Hotels near University of Texas Health and Science Center at San Antonio
- Hotels near St. Mark's Episcopal Church
- Hotels near Witte Museum
- Hotels near Historic Sunset Station
- North Central Hotels
- Hotels near Carver Community Cultural Center
- Hotels near San Antonio Station
- Hotels near The DoSeum
- Hotels near San Fernando De Bexar Cathedral
- Hotels near Dry Comal Creek Winery & Vineyards
- Hotels near Alamodome
- Hotels near Aquatica San Antonio Waterpark
- Hotels near Oak Hills Country Club
- Castle Hills Hotels
- Fredericksburg Hotels
- Kirby Hotels
- Hotels near Ripley's Believe It or Not!
- Southtown Hotels
- Vance Jackson Hotels
- Hotels near Briscoe Western Art Museum
- Hidden Creek Hotels
- Midtown Hotels
- Woodstone Hotels
- Hotels near The Amazing Mirror Maze
- Olmos Park Hotels
- Hotels near San Antonio Intl.
- Hotels near Basilica of the National Shrine of the Little Flower
- Hotels near San Antonio Zoo and Aquarium
- Hotels near River Walk
- Hotels near Arneson River Theatre
- Hotels near San Pedro Driving Range & Par 3 Course
- Hotels near Cathedral of San Fernando
- Jefferson Hotels
- Hotels near Blue Star Art Space Museum
- Hotels near South Texas Medical Center
- Hotels near Magik Theater
- Hotels near San Pedro Springs Park
- Hotels near El Mercado
- Woods of Shavano Hotels
- Hotels near Milam Park
- Hotels near Tower Life Building
- Boerne Hotels
- Fort Sam Houston Hotels
- Hotels near Historic Brackenridge Golf Course
- Hotels near San Marcos Station
- Stone Oak Hotels
- Hotels near Spanish Governor's Palace
- Hotels near Wonderland of the Americas Mall
- Hotels near Marion Koogler McNay Art Museum
- Hotels near Charline McCombs Empire Theatre
- Tobin Hill Hotels
- Hotels near Market Square
- Riverside Hotels
- Hotels near McFarlin Tennis Center
- Hotels near North Star Mall
- Hotels near San Antonio Convention & Visitors Bureau
- Hotels near Rolling Oaks Mall
- Hotels near St Joseph Catholic Church
- Hotels near Henry B. González Convention Center
- Vista Verde South Hotels
- St. Paul Square Hotels
- Helotes Hotels
- Hotels near Trinity Baptist Church
- San Antonio Hotels
- Hotels near Frost Bank Center
- Hotels near The Guadalupe Cultural Arts Center
- Hotels near Blessed Sacrament Catholic Church
- Hotels near Woodlawn Theater
- Balcones Heights Hotels
- Hotels near Lackland Air Force Base
- Hotels near University of Texas at San Antonio
- Hotels near The Shops of La Cantera
- Park Village Hotels
- Downtown San Antonio Hotels
- Hotels near USAA Corporate Office Headquarters
- Hotels near Brackenridge Park
- Hotels near Buckhorn Saloon and Museum
- Hotels near San Antonio Majestic Theater
- Hotels near Guenther House
- Hotels near Texas Music Theater
- Hotels near Six Flags Fiesta Texas
- Pearl District Hotels
- Mahncke Park Hotels
- Hotels near Alamo
- Terrell Hills Hotels
- Main - Military Plaza Hotels
- Oak Park - Northwood Hotels
- Hotels near Monster Mini Golf
- Garden Ridge Hotels
- River Road Hotels
- Hotels near Blue Star Contemporary Art Center
- Hotels near Travis Park
- Alamo Heights Hotels
- Shearer Hills - Ridgeview Hotels
- Hotels near The Rim Shopping Center
- Uptown Hotels
- New Braunfels Hotels






















































































