A cityscape with a prominent tower, a large body of water, and a sunset.

Find hotels in Medical Center District, San Antonio

Check prices for these dates

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Medical Center District hotels

1. Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk
4.0 star property
Downtown San Antonio, 7.6 mi from Medical Center District
9.4 out of 10, Exceptional, (5,503 reviews)
"Excellent place, great location"
United States
Rafael
$128 nightly
The price is $153
Nov 22 - Nov 23
Total with taxes and fees
Drury Plaza Hotel San Antonio Riverwalk

2. Hotel Valencia Riverwalk, Valencia Collection

Hotel Valencia Riverwalk, Valencia Collection
4.5 star property
Downtown San Antonio, 7.5 mi from Medical Center District
9.4 out of 10, Exceptional, (3,319 reviews)
"Great place to stay"
United States
Derrick
$161 nightly
The price is $192
Nov 23 - Nov 24
Total with taxes and fees
Hotel Valencia Riverwalk, Valencia Collection

3. Riverwalk Plaza

Riverwalk Plaza
4.0 star property
7.7 mi from Medical Center District
8.0 out of 10, Very good, (6,509 reviews)
"Great stay"
United States
Samantha
$91 nightly
The price is $109
Dec 13 - Dec 14
Total with taxes and fees
Riverwalk Plaza

4. Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
3.5 star property
Far West Side, 7 mi from Medical Center District
9.0 out of 10, Wonderful, (2,076 reviews)
"Excellent vacation location."
United States
Eric
$113 nightly
The price is $135
Dec 1 - Dec 2
Total with taxes and fees
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

5. Menger Hotel

Menger Hotel
3.5 star property
Downtown San Antonio, 7.9 mi from Medical Center District
8.6 out of 10, Excellent, (4,500 reviews)
"Excellent place to stay ❤️"
United States
Enrique
$90 nightly
The price is $108
Nov 15 - Nov 16
Total with taxes and fees
Menger Hotel

6. The Westin San Antonio North

The Westin San Antonio North
4.0 star property
2.1 mi from Medical Center District
8.4 out of 10, Very good, (1,659 reviews)
"we had a wonderful stay"
United States
Diana
$88 nightly
The price is $105
Nov 22 - Nov 23
Total with taxes and fees
The Westin San Antonio North

7. Omni La Mansion del Rio

Omni La Mansion del Rio
4.0 star property
Downtown San Antonio, 7.6 mi from Medical Center District
9.4 out of 10, Exceptional, (3,019 reviews)
"Perfect anniversary getaway!"
United States
jenny
$172 nightly
The price is $205
Nov 15 - Nov 16
Total with taxes and fees
Omni La Mansion del Rio

8. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very good, (3,781 reviews)
"Great place to stay"
United States
Gilbert
$89 nightly
The price is $106
Nov 15 - Nov 16
Total with taxes and fees
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

9. Hotel Contessa

Hotel Contessa
4.0 star property
Downtown San Antonio, 7.8 mi from Medical Center District
9.0 out of 10, Wonderful, (4,061 reviews)
"Great place to stay."
United States
Stephanie
$139 nightly
The price is $166
Dec 13 - Dec 14
Total with taxes and fees
Hotel Contessa

10. Hyatt Regency San Antonio Riverwalk

Hyatt Regency San Antonio Riverwalk
4.0 star property
Downtown San Antonio, 7.7 mi from Medical Center District
9.2 out of 10, Wonderful, (2,341 reviews)
"excellent location..food was great"
United States
Donna M
$188 nightly
The price is $224
Nov 22 - Nov 23
Total with taxes and fees
Hyatt Regency San Antonio Riverwalk

11. La Cantera Resort & Spa, a Signia Hilton Resort

La Cantera Resort & Spa, a Signia Hilton Resort
4.0 star property
La Cantera District, 7.2 mi from Medical Center District
9.0 out of 10, Wonderful, (1,065 reviews)
"Amazing stay"
United States
desarae
$355 nightly
The price is $422
Nov 29 - Nov 30
Total with taxes and fees
La Cantera Resort & Spa, a Signia Hilton Resort

12. Hyatt Regency Hill Country Resort and Villas

Hyatt Regency Hill Country Resort and Villas
4.0 star property
Far West Side, 7 mi from Medical Center District
8.8 out of 10, Excellent, (1,000 reviews)
"Beautiful place and 100% recommend"
United States
Brad
$385 nightly
The price is $459
Nov 15 - Nov 16
Total with taxes and fees
Hyatt Regency Hill Country Resort and Villas

13. Hotel 1914 - Historic Alamo Riverwalk, an Ascend Collection Hotel

Hotel 1914 - Historic Alamo Riverwalk, an Ascend Collection Hotel
4.0 star property
Downtown San Antonio, 7.6 mi from Medical Center District
8.0 out of 10, Very good, (576 reviews)
"Historic hotel has its kinks but the pool was so nice and restaurant was amazing.would stay again"
United States
Amy
$86 nightly
The price is $101
Nov 15 - Nov 16
Total with taxes and fees
Hotel 1914 - Historic Alamo Riverwalk, an Ascend Collection Hotel

14. San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1,200 reviews)
"Room was clean, very friendly staff"
Canada
Hsiao Tung
$94 nightly
The price is $112
Dec 13 - Dec 14
Total with taxes and fees
San Antonio Marriott Northwest Medical Center

15. Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1,535 reviews)
"Nice overnight stay."
United States
Sharon
$90 nightly
The price is $107
Nov 22 - Nov 23
Total with taxes and fees
Drury Inn & Suites San Antonio Northwest Medical Center

16. La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3.0 star property
Downtown San Antonio, 8.1 mi from Medical Center District
8.0 out of 10, Very good, (4,092 reviews)
"Great place to stay"
United States
Manuel
$93 nightly
The price is $111
Nov 18 - Nov 19
Total with taxes and fees
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

17. Crockett Hotel

Crockett Hotel
3.0 star property
Downtown San Antonio, 7.9 mi from Medical Center District
8.8 out of 10, Excellent, (2,852 reviews)
"Great place"
United States
Rodney
$76 nightly
The price is $91
Nov 15 - Nov 16
Total with taxes and fees
Crockett Hotel

18. Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1,002 reviews)
"Great property, nice rooms"
United States
Francisca
$89 nightly
The price is $106
Nov 26 - Nov 27
Total with taxes and fees
Courtyard by Marriott Medical Center San Antonio

19. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
2.5 star property
Uptown Central, 5.8 mi from Medical Center District
9.0 out of 10, Wonderful, (2,410 reviews)
"Clean room, breakfast was great and filling. Hotel is super comfortable and easy city accesible."
United States
David
$79 nightly
The price is $94
Nov 15 - Nov 16
Total with taxes and fees
Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

20. La Quinta Inn & Suites by Wyndham San Antonio Downtown

La Quinta Inn & Suites by Wyndham San Antonio Downtown
3.0 star property
Arsenal, 7.7 mi from Medical Center District
9.0 out of 10, Wonderful, (3,670 reviews)
"Wonderful stay very pleasant..great location easy walking distances for sightseeing. Definitely would book again!"
United States
Glen
$91 nightly
The price is $108
Nov 22 - Nov 23
Total with taxes and fees
La Quinta Inn & Suites by Wyndham San Antonio Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Medical Center District

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.
Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
9.2
Wonderful
1,535 reviews
View
A swimming pool with a wooden ceiling, lounge chairs, and a view of trees and a building.
Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
9.0
Wonderful
1,116 reviews
View
A modern bar area with wooden bar counters, black bar stools, and pendant lighting.
Courtyard by Marriott Medical Center San Antonio
3.0 star property
8.8
Excellent
1,002 reviews
View
A reception area with three wooden reception desks, a marble counter, and a wall-mounted display.
San Antonio Marriott Northwest Medical Center
3.5 star property
8.6
Excellent
1,200 reviews
View
A conference room with round tables, orange chairs, and purple lighting.
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
8.4
Very good
3,781 reviews
View

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District

Downtown San Antonio

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Uptown Central

While visiting Uptown Central, you might make a stop by sights like Marion Koogler McNay Art Museum and Alamo Quarry Market.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Northwest Side

While visiting Northwest Side, you might make a stop by sights like Huebner Oaks and Crystal Ice Palace.

Stone Oak

Travelers come to Stone Oak for its abundant dining options, and you can see top attractions like Shops at Hardy Oak and Alta Vista at Stone Oak while you're in town.

Top Medical Center District Hotel Reviews

Frequently asked questions

What are the best hotels in Medical Center District that travelers recommend?
Two highly recommended hotels in the Medical Center District are the San Antonio Marriott Northwest Medical Center and the SpringHill Suites by Marriott San Antonio Medical Center/NW.

The 3.5-star San Antonio Marriott Northwest Medical Center, with an 8.6 rating, offers comfortable and clean rooms, along with exceptional and friendly staff. Guests appreciate the champagne service, bathrobes, and designer toiletries, ensuring a luxurious stay. It is conveniently located near Dellview Park and the First Unitarian Universalist Church.

Another excellent option is the 3-star SpringHill Suites by Marriott San Antonio Medical Center/NW, which boasts an 8.8 rating. This hotel provides spacious and clean suites, and travelers frequently praise the friendly and helpful staff. Guests can also enjoy a good variety of complimentary breakfast options. It is perfectly situated near the Wonderland of the Americas Mall and the First Unitarian Universalist Church.
What are the best family hotels in Medical Center District?
For family-friendly hotels in the Medical Center District, consider the Drury Inn & Suites San Antonio Northwest Medical Center, the Courtyard by Marriott Medical Center San Antonio, or the SpringHill Suites by Marriott San Antonio Medical Center/NW.

The 3-star Drury Inn & Suites San Antonio Northwest Medical Center, with an impressive 9.2 rating, is an excellent choice for families. It offers complimentary breakfast, including a buffet, and rooms with sofa beds and free cribs, making it convenient for those traveling with children. Guests consistently praise the friendly staff and comfortable, clean rooms.

Another highly-rated option is the 3-star Courtyard by Marriott Medical Center San Antonio, which has an 8.8 rating. This hotel provides free WiFi and self-parking, along with free rollaway beds and cribs. Families will appreciate the on-site pool and the availability of connecting rooms. Guests frequently comment on the quiet location and comfortable rooms.

The 3-star SpringHill Suites by Marriott San Antonio Medical Center/NW, also rated 8.8, is another great family hotel. It offers a complimentary continental breakfast, an on-site pool, and rooms with sofa beds and free cribs. Guests appreciate the spacious and clean rooms, as well as the helpful staff. It is conveniently located near points of interest like the Wonderland of the Americas Mall, which is just 0.2 miles away.
What hotels in Medical Center District offer free breakfast?
For hotels in the Medical Center District that offer complimentary breakfast, consider the 3-star Drury Inn & Suites San Antonio Northwest Medical Center, the Fairfield Inn & Suites by Marriott San Antonio Medical Center, the 3-star SpringHill Suites by Marriott San Antonio Medical Center/NW, or the 3-star La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW.

The 3-star Drury Inn & Suites San Antonio Northwest Medical Center, with a 9.2 rating, provides a free buffet breakfast and also offers a free area shuttle. Guests frequently mention the friendly staff, comfortable and clean rooms, and the excellent breakfast. The San Antonio Art Institute is conveniently located just 0.2 miles away.

Another great option is the Fairfield Inn & Suites by Marriott San Antonio Medical Center, which has a 9.0 rating and offers free breakfast. Reviewers often highlight the friendly staff, comfortable rooms, and excellent breakfast.

The 3-star SpringHill Suites by Marriott San Antonio Medical Center/NW, rated 8.8, includes a free continental breakfast and offers a to-go breakfast option. Guests appreciate the spacious and clean rooms, the friendly staff, and the good variety at breakfast. It's located 0.2 miles from Wonderland of the Americas Mall.

Lastly, the 3-star La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW, with an 8.4 rating, also provides a free buffet breakfast. Travelers often praise the friendly staff, clean rooms, and a great breakfast.
What are the top pet-friendly hotels in Medical Center District?
For top pet-friendly hotels in the Medical Center District, consider the San Antonio Marriott Northwest Medical Center, the Drury Inn & Suites San Antonio Northwest Medical Center, and the Courtyard by Marriott Medical Center San Antonio.

The 3.5-star San Antonio Marriott Northwest Medical Center, with a rating of 8.6, is a great choice for pet owners, offering a dedicated dog exercise area and permitting dogs. Guests frequently praise its comfortable and clean rooms, exceptional staff, and superb location. It is conveniently located near the First Unitarian Universalist Church and Dellview Park.

Another excellent option is the 3-star Drury Inn & Suites San Antonio Northwest Medical Center, which boasts an impressive 9.2 rating. This hotel welcomes both dogs and cats and provides complimentary breakfast, including a buffet. Travelers consistently praise its friendly staff, comfortable and clean rooms, and excellent location.

The 3-star Courtyard by Marriott Medical Center San Antonio, rated 8.8, also permits pets and offers free WiFi, free toiletries, and complimentary cribs. Guests appreciate its quiet location, comfortable and clean rooms, and friendly staff. The convenient self-parking is also a frequently mentioned benefit.
What are the best budget hotels in Medical Center District?
For excellent budget-friendly hotels in the Medical Center District, consider the Drury Inn & Suites San Antonio Northwest Medical Center and the SpringHill Suites by Marriott San Antonio Medical Center/NW.

The 3-star Drury Inn & Suites San Antonio Northwest Medical Center, with an impressive 9.2 rating, offers a complimentary buffet breakfast and free area shuttle service, making it very convenient for exploring. Guests frequently praise the friendly staff, comfortable rooms, and excellent location. It is also just 0.2 miles from The San Antonio Art Institute.

Another great option is the 3-star SpringHill Suites by Marriott San Antonio Medical Center/NW, rated 8.8. This hotel provides a complimentary continental breakfast and free self-parking. Travelers appreciate the spacious and clean rooms, the friendly staff, and the good variety at breakfast. It is conveniently located near Wonderland of the Americas Mall, just 0.2 miles away.
What are the most romantic hotels in Medical Center District for couples?
For romantic hotels in the Medical Center District for couples, consider the San Antonio Marriott Northwest Medical Center and the La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW.

The 3.5-star San Antonio Marriott Northwest Medical Center, with an 8.6 rating, offers comfortable and clean rooms, which guests frequently praise. The hotel features an inviting outdoor pool with sun loungers and umbrellas, great for relaxing together. Its location is often described as perfect, and the staff and food receive exceptional reviews.

Another option is the 3-star La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW, rated 8.4. This hotel provides a relaxing hot tub and complimentary buffet breakfast, making for a convenient and pleasant start to your day. Guests consistently highlight the friendly and great staff, as well as the comfortable and clean rooms.
What are the best hotels in Medical Center District near Cinemark San Antonio 16?
For a highly-rated hotel in the Medical Center District near Cinemark San Antonio 16, consider the Fairfield Inn & Suites by Marriott San Antonio Medical Center.

This hotel, with a 9.0 rating, is conveniently located just one mile from Cinemark San Antonio 16. Guests frequently praise the comfortable and clean rooms, as well as the friendly and great staff. It offers a complimentary buffet breakfast, a pool, and options for connecting rooms, free cribs, and free rollaway extra beds, making it an excellent choice for families.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Medical Center District.
How much is the nightly rate at a Medical Center District hotel?
Prices for hotels in Medical Center District often vary, but you can find a great deal on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia